​What is Type I Diabetes?

 

Type I diabetes (T1D) is a chronic autoimmune condition in which the body’s immune system attacks insulin-producing beta cells in the pancreas. This leads to little or no insulin production, making it difficult for the body to regulate blood sugar levels. Unlike Type II diabetes, T1D is not linked to lifestyle factors but is influenced by genetic and environmental factors. Key Characteristics:

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• Typically diagnosed in children and young adults, though it can occur at any age.

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• Symptoms include excessive thirst, frequent urination, extreme fatigue, weight loss, and blurred vision.

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• Management requires lifelong insulin therapy, blood sugar monitoring, and dietary management.

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Schematic illustration showing the molecular mechanism of Type I diabetes.

 

Global Incidence of Type I Diabetes

 

The incidence of T1D varies significantly across countries and regions. Below is an overview of the global burden:​​

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This plot was generated integrating informations from different international sources: International Diabetes Federation, World Health Organization and National Diabetes Statistics Report

 

 

Type I diabetes is a global health challenge with varying incidence rates worldwide. High-quality data collection and awareness initiatives are crucial for understanding its burden and improving outcomes for those affected. 

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Here we aim to use our proprietary symbiotic therapy system to treat mice and NHP models of T1D. In particular symbiotic particles injected under host skin will release over time an improved version of insulin at low and constant rates replacing pancreatic beta cells function.

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